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Pulmozyme is an important part of a multitherapy approach to treating CF

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Preparing for treatment
Nebulizer

Learn how to take Pulmozyme

Pulmozyme administration

Equipment needed for taking Pulmozyme

Administer Pulmozyme via a jet nebulizer connected to an air compressor with an adequate air flow and equipped with a mouthpiece or suitable face mask, or via a vibrating mesh nebulizer.

Follow the Manufacturer’s Instructions for Use on the use, maintenance, and replacement of the equipment, including cleaning and disinfection procedures.

For additional information, refer to the selected nebulizer Manufacturer’s Instructions for Use.

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Pulmozyme is a prescription medicine indicated along with standard therapies, for the management of pediatric and adult patients with cystic fibrosis (CF) to improve lung function. It works by breaking down DNA in airway mucus, reducing its thickness and helping clear the airways. Pulmozyme is administered as an inhalation via a nebulizer, typically once daily. Some patients may benefit from twice-daily use. Your healthcare provider will determine your dosing schedule based on your needs.

Common side effects of Pulmozyme include voice changes, sore throat, rash, chest pain, and eye irritation. You should call your doctor if you experience any of these side effects or if any of these side effects are severe, get worse, or do not go away.

Important Safety Information

Indication and Usage

Pulmozyme (dornase alfa) is indicated, along with standard therapies, for the management of pediatric and adult patients with cystic fibrosis (CF) to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion, and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

Pediatric Use

The safety and effectiveness of Pulmozyme along with standard therapies for cystic fibrosis have been established in pediatric patients. The use of Pulmozyme in pediatric patients at 5 to 17 years of age is supported by evidence from a randomized, controlled trial. The use of Pulmozyme in patients less than 5 years of age is supported by the efficacy data from the same randomized, controlled trial and additional safety data in pediatric patients aged 3 months to less than 5 years who received Pulmozyme.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

For further information, please see the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF Care Team.